|ISEV2016 Plenary Speakers|
Plenary Speakers at ISEV2016
David C Lyden M.D. Ph.D. is professor at Weill Cornell Medical College. He received his MD at Brown University School of Medicine and his PhD at the University of Vermont. He completed a residency in pediatrics at Duke University and fellowship in oncology at Memorial Sloan-Kettering Cancer Center. Prof Lyden’s group made several fundamental discoveries that involve the role of bone marrow-derived stem and progenitor cells in tumor vasculogenesis and in metastasis. Among several other milestone discoveries, his laboratory defined the concept of the "pre-metastatic niche", showing that in response to tumor-secreted factors, tumor-associated cells such as hematopoietic progenitor cells are recruited to future metastatic niches creating an environment that is conducive for tumor cell adhesion and invasion. His group has demonstrated the role of tumor-derived exosomes in pre-metastatic niche formation, and provided evidence that tumor-derived exosome cargo also includes double-stranded DNA, representing the entire genome of the tumor cell of origin. He is a recipient of many honors and awards. His work was highlighted in “Nature Milestones: Cancer”, and he has been featured as one of fifteen cancer experts in the book Why Millions Survive Cancer: The Successes of Science (author: Lauren Pecorino, Oxford Univ. Press).
Robert C. Gallo M.D. is professor and director of the Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland and Scientific Director of the Global Virus Network. Prof Gallo received MD from Jefferson Medical College in Philadelphia, Pennsylvania in 1963. After completing his medical residency at the University of Chicago, he became a researcher at the National Cancer Institute, where he worked for 30 years, mainly as head of the Laboratory of Tumor Cell Biology. Prof Gallo’s group identified T-cell growth factor (also known as IL-2), a critical factor required for the growth and maintenance in culture of T cells. In 1982, he received Lasker Award: "For his pioneering studies that led to the discovery of the first human RNA tumor virus (the old name for retroviruses) and its association with certain leukemias and lymphomas." He was awarded his second Lasker Award in 1986 for "determining that the retrovirus now known as HIV-1 is the cause of Acquired Immune Deficiency Syndrome (AIDS).” He is the only recipient of two Lasker Awards. Of huge significance to global public health, is Prof Gallo’s role in the development of a robust, simple blood test for the human immunodeficiency virus that became a worldwide tool. Prof Gallo has received 26 honorary degrees from the universities all over the world.
Leonid Margolis Ph.D. DSc. graduated from Lomonosov University, Moscow with degrees in mathematics and biology. He received a Ph.D. in Oncology and an advanced degree of Doctor of Science in Biophysics. In 1991, he was elected a member of the Russian Academy of Natural Sciences. Dr. Margolis worked as a Visiting Professor at the University of San Diego, University of Stuttgart, and Kings College, London. In 1994 he was selected to be a Fogarty Scholar-in-Residence at NIH. He joined NICHD in 1995 and is Chief of the Section of Intercellular Interactions, within the Program in Physical Biology. He developed a system of ex vivo human lymphoid tissues through which he and others investigated critical mechanisms of tissue pathogenesis of HIV-1 and other viruses under controlled laboratory conditions. The experimental tissue systems developed by Dr. Margolis and his team are widely used as platforms for the study of HIV pathogenesis and for testing antivirals. Currently, his research is focused on inter-viral interactions in human tissues, the transmission of HIV-1 and herpesviruses, and the development of new antivirals, in particular microbicides. Dr. Margolis has received several NIH Director’s Awards, is involved in various international collaborative activities, and is an Adjunct Scientist of MSU and the Ilia University of the Republic of Georgia.
Francisco Sánchez-Madrid Ph.D. is Professor at the Universidad Autónoma de Madrid and is Head of the Immunology Department in the La Princesa Hospital in Madrid. He graduated in 1976 from the University of Seville, and he has received his Ph.D. in 1980. From 1980 to 1983 he worked as a postdoctoral fellow at Harvard Medical School, Boston. His team in Madrid has pioneered the development of imaging technologies (microscopy) to visualize the migratory processes and behavior of the receptors that take part in the immune process. His laboratory has contributed to: 1) identification and establishment of cell surface receptors as markers for the two poles of a polarized migrating leukocyte; chemokine receptors at the leading edge, and adhesion receptors ICAMs at the uropod; 2) chemokines as the physiological mediators of leukocyte polarization prior to cell migration; 3) membrane receptor-cytoskeletal interactions that drive cell polarity. Furthermore, his team made important observations regarding the polarized delivery of exosomes in highly polarized cells; regulation of exosome loading; sorting of miRNAs into exosomes; analysis of exosomes of the immune synapse. Prof Sanchez-Madrid has published over 350 scientific papers, and he is featured in the Thomson Reuters list of the 250 most highly-cited researchers in Immunology.